Blood-brain barrier transport of morphine in patients with severe brain trauma

Blood-brain barrier transport of morphine in patients with severe brain trauma.

AIMS In experimental studies, morphine pharmacokinetics is different in the brain compared with other tissues due to the properties of the blood-brain barrier, including action of efflux pumps. It was hypothesized in this clinical study that active efflux of morphine occurs also in human brain, and that brain injury would alter cerebral morphine pharmacokinetics. METHODS Patients with traumat...

Neuroprotective Effects of Allicin on Neurological Scores, Blood Brain Barrier Permeability and Brain Edema Following Severe Traumatic Brain Injury in Male Rats: A Behavioral, Biochemical and Histological Study

 Background and purpose: Allicin has a wide range of pharmacological functions, all of which can be demonstrated in anti-inflammatory, antioxidant, antifungal and anti-tumor activities. In this research, we investigated the neuroprotective role of allicin in the process of diffuse traumatic brain injury and its effect on interleukin levels and histological changes in rats. Materials and method...

P45: The Role of Blood-Brain Barrier Breakdown Following Traumatic Brain in Post-Traumatic Epilepsy

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Intensification of brain injury and blood-brain barrier permeability by short-term hypertension in experimental model of brain ischemia/reperfusion

Introduction: Arterial hypertension is one of the causes of stroke, and as one of the vasculotoxic conditions intensifies ischemic stroke complications. The aim of the present study was to analyze the effects of short-term cerebral hypertension on ischemia/reperfusion injury and pathogenesis of ischemic stroke. Methods: The experiments were performed on three groups of rats (N=36) Sham, cont...

Pharmacokinetics and Pharmacodynamics of Oxycodone and Morphine with Emphasis on Blood-Brain Barrier Transport